Abstract Isopropyl alcohol (IPA) catalytic oxidation remains one of the most popular techniques to remove volatile organic compounds from indoor places. In our study, catalytic oxidation of IPA was investigated on catalysts based on platinum deposited on mullite (Al6Si2O13), known for its excellent thermal stability. Pt/Al6Si2O13 catalysts were prepared by impregnation with and without methyl cellulose (MC) and were tested in order to study the influence of MC on the platinum particle dispersion over the support. The catalytic reactivity was compared with Pt/α-alumina and Pt/SiO2. Moreover, the resulting materials were characterized by BET, XRD, TEM and H2-chemisorption. This study showed that platinum exhibits better dispersion on alumina sites than silica sites. This can be due to a strong interaction between platinum and alumina, leading to a higher dispersion of platinum species. Furthermore, the addition of MC enhanced the Pt dispersion over the mullite, leading to an improvement in the catalytic performance.